Dr. Konstantinos Theofilatos
Education
| 2001-2006 | Bachelor of Science Department of Computer Engineering and Informatics University of Patras, Greece |
| 2006-2009 | Master of Science in Computer Science and Engineering Department of Computer Engineering and Informatics University of Patras, Greece |
| 2009-2013 | PhD in Computer Engineering and Informatics Department of Computer Engineering and Informatics University of Patras, Greece |
Present Appointment
| 2017- | Lecturer School of Cardiovascular Medicine & Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK |
Previous Appointment
| 2015-2017 | Co-Founder and Chief Technology Officer (CTO) InSyBio Ltd, United Kingdom (www.insybio.com) |
| 2013-2015 | Post Doctoral Researcher Neurophysiology Unit, Medicine School, University of Patras, Greece |
| 2014-2015 | Software Analyst – Computer Programmer Information Technology Support Center of the Hellenic Army of General Staff (KEPYES) |
Publications
| 1 | Mosquera JV, Auguste G, Wong D, Turner AW, Hodonsky CJ, Alvarez-Yela AC, Song Y, Cheng Q, Cardenas CL, Theofilatos K, Bos M, Kavousi M, Peyser PA, Mayr M, Kovacic JC, Björkegren JLM, Malhotra R, Stukenberg PT, Finn AV, van der Laan SW, Zang C, Sheffield NC, Miller CL. Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis. Cell Reports. 2023 42(11) : . [Full Text] [PubMed] [DOI] |
| 2 | Loos M, Klampe B, Schulze T, Yin X, Theofilatos K, Ulmer BM, Schulz C, Behrens CS, van Bergen TD, Adami E, Maatz H, Schweizer M, Brodesser S, Skryabin BV, Rozhdestvensky TS, Bodbin S, Stathopoulou K, Christ T, Denning C, Hübner N, Mayr M, Cuello F, Eschenhagen T, Hansen A. Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism. Stem Cell Reports. 2023 18(11) : 2123-2137. [Full Text] [PubMed] [DOI] |
| 3 | Theofilatos K, Stojkovic S, Hasman M, van der Laan SW, Baig F, Barallobre-Barreiro J, Schmidt LE, Yin S, Yin X, Burnap S, Singh B, Popham J, Harkot O, Kampf S, Nackenhorst MC, Strassl A, Loewe C, Demyanets S, Neumayer C, Bilban M, Hengstenberg C, Huber K, Pasterkamp G, Wojta J, Mayr M. Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes. Circulation Research. 2023 133(7) : 542-558. [Full Text] [PubMed] [DOI] |
| 4 | Romeo SG, Secco I, Schneider E, Reumiller CM, Santos CX, Zoccarato A, Musale V, Pooni A, Yin X, Theofilatos K, Trevelin SC, Zeng L, Mann GE, Pathak V, Harkin K, Stitt AW, Medina RJ, Margariti A, Mayr M, Shah AM, Giacca M, Zampetaki A. Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity. Nature Communications. 2023 14(1) : 5552. [Full Text] [PubMed] [DOI] |
| 5 | Hasman M, Mayr M, Theofilatos K. Uncovering Protein Networks in Cardiovascular Proteomics. Molecular & Cellular Proteomics. 2023 22(8) : 100607. [Full Text] [PubMed] [DOI] |
| 6 | Ragone I, Barallobre-Barreiro J, Takov K, Theofilatos K, Yin X, Schmidt LE, Domenech N, Crespo-Leiro MG, van der Voorn SM., Vink A, van Veen TA.B., Bödör C, Merkely B, Radovits T, Mayr M. SERCA2a Protein Levels Are Unaltered in Human Heart Failure. Circulation. 2023 148(7) : 613–616. [Full Text] [PubMed] [DOI] |
| 7 | Clarke R, Von Ende A, Schmidt L E, Yin X, Hill M, Hughes A D, Pechlaner R, Willeit J, Kiechl S, Watkins H, Theofilatos K, Hopewell J C, Mayr M, PROCARDIS Consortium. Apolipoprotein Proteomics for Residual Lipid-Related Risk in Coronary Heart Disease. Circulation Research. 2023 132(4) : 452-464. [Full Text] [PubMed] [DOI] |
| 8 | Duregotti E, Reumiller CM, Mayr U, Hasman M, Schmidt LE, Burnap SA, Theofilatos K, Barallobre-Barreiro J, Beran A, Grandoch M, Viviano A, Jahangiri M, Mayr M. Reduced secretion of neuronal growth regulator 1 contributes to impaired adipose-neuronal crosstalk in obesity. Nature communications. 2022 13(1) : 7269. [Full Text] [PubMed] [DOI] |
| 9 | Schulte C, Singh B, Theofilatos K, Sörensen NA, Lehmacher J, Hartikainen T, Haller PM, Westermann D, Zeller T, Blankenberg S, Neumann JT, Mayr M . Serial measurements of protein and microRNA biomarkers to specify myocardial infarction subtypes. Journal of molecular and cellular cardiology plus. 2022 1 : 100014. [Full Text] [PubMed] [DOI] |
| 10 | Yin X, Takov K, Straube R, Voit-Bak K, Graessler J, Julius U, Tselmin S, Rodionov R, Barbir M, Walls M, Theofilatos K, Mayr M, Bornstein SR. Precision Medicine Approach for Cardiometabolic Risk Factors in Therapeutic Apheresis. Hormone and Metabolic Research. 2022 54(04) : 238-249. [PubMed] [DOI] |
| 11 | Dave J, Raad N, Mittal N, Zhang L, Fargnoli A, Oh JG, Savoia ME, Hansen J, Fava M, Yin X, Theofilatos K, Ceholski D, Kohlbrenner E, Jeong D, Wills L, Nonnenmacher M, Haghighi K, Costa KD, Turnbull IC, Mayr M, Cai C-L, Kranias EG, Akar FG, Hajjar RJ, Stillitano F. Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact. Cardiovascular Research. 2022 : . [Full Text] [PubMed] [DOI] |
| 12 | Joshi A, Schmidt LE, Burnap SA, Lu R, Chan MV, Armstrong PC, Baig F, Gutmann C, Willeit P, Santer P, Barwari T, Theofilatos K, Kiechl S, Willeit J, Warner T, Mathur A, Mayr M. Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity. Arteriosclerosis, thrombosis, and vascular biology. 2021 : ATVBAHA-121. [Full Text] [PubMed] [DOI] |
| 13 | Barallobre-Barreiro J, Radovits T, Fava M, Mayr U, Lin WY, Ermolaeva E, Martínez-López D, Lindberg EL, Duregotti E, Daróczi L, Hasman M, Schmidt LE, Singh B, Lu R, Baig F, Siedlar AM, Cuello F, Catibog N, Theofilatos K, Shah AM, Crespo-Leiro MG, Doménech N, Hübner N, Merkely BP, Mayr M. The Extracellular Matrix in Heart Failure: The Role of Adamts5 In Proteoglycan Remodelling. Circulation. 2021 : . [Full Text] [PubMed] [DOI] |
| 14 | Gutmann C, Khamina K, Theofilatos K, Diendorfer AB, Burnap S, Nabeebaccus A, Fish M, McPhail M, Schmidt L, Cassel C, Auzinger G. Association of cardiometabolic microRNAs with COVID-19 severity and mortality. Cardiovascular Research. 2021 : . [Full Text] [PubMed] [DOI] |
| 15 | Burnap SA, Sattler K, Pechlaner R, Duregotti E, Lu R, Theofilatos K, Takov K, Heusch G, Tsimikas S, Fernández-Hernando C, Berry SE. PCSK9 Activity Is Potentiated Through HDL Binding. Circulation Research. 2021 : . [Full Text] [PubMed] [DOI] |
| 16 | Burnap SA, Sattler K, Pechlaner R, Theofilatos K, Takov K, Heusch G, Tsimikas S, Fernández-Hernando C, Berry SE, Hall W, Notdurfter M. HDL compartmentalisation regulates PCSK9 activity. Atherosclerosis. 2021 331 : e39. [Full Text] [DOI] |
| 17 | Eijgenraam TR, Boogerd CJ, Stege NM, Oliveira Nunes Teixeira V, Dokter MM, Schmidt LE, Yin X, Theofilatos K, Mayr M, van der Meer P, van Rooij E. Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del–Related Cardiomyopathy. Circulation: Heart Failure. 2021 : CIRCHEARTFAILURE-121. [Full Text] [PubMed] [DOI] |
| 18 | Sangiao-Alvarellos S, Theofilatos K, Barwari T, Gutmann C, Takov K, Singh B, Juiz-Valiña P, Varela-Rodríguez BM, Outeiriño-Blanco E, Duregotti E, Zampetaki A, Lunger L, Ebenbichler C, Tilg H, García-Brao MJ, Willeit P, Mena E, Kiechl S, Cordido F, Mayr M. Metabolic recovery after weight loss surgery is reflected in serum microRNAs. BMJ Open Diabetes Research and Care. 2020 8(2) : e001441. [Full Text] [PubMed] [DOI] |
| 19 | Gutmann C, Takov K, Burnap S, Singh B, Theofilatos K, Reed E, Hasman M, Nabeebaccus A, Fish M, McPhail M, O'Gallagher K, Schmidt L, Cassel C, Rienks M, Yin X, Auzinger G, Napoli S, Mujib S, Trovato F, Sanderson B, Merrick B, Niazi U, Saqi M, Dimitrakopoulou K, Braun S, Kronstein-Wiedemann R, Doores K, Edgeworth J, Shah A, Bornstein S, Tonn T, Hayday A, Shankar-Hari M, Mayr M. SARS-CoV-2 RNAemia and proteomic biomarker trajectory inform prognostication in COVID-19 patients admitted to intensive care. . 2020 : . [Full Text] [DOI] |
| 20 | Schulte C, Barwari T, Joshi A, Theofilatos K, Zampetaki A, Barallobre-Barreiro J, Singh B, Sorensen N, Neumann JT, Zeller T, Westermann D.. Comparative Analysis of Circulating Non-Coding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury. Circulation research. 2019 Epub : . [Full Text] [PubMed] [DOI] |
| 21 | Corthesy J, Theofilatos K, Mavroudi S, Macron C, Cominetti O, Remlawi M, Ferraro F, Nuez Galindo A, Kussmann M, Likothanassis S, Dayon L.. An adaptive pipeline to maximize isobaric tagging data in large-scale MS-based proteomics. Journal of proteome research. 2018 17 : 2165-73. |
| 22 | Theofilatos K, Dimitrakopoulos C, Alexakos C, Korfiati A, Likothanassis S, Mavroudi S. InSyBio BioNets: an efficient tool for network-based biomarker discovery . EMBnet Journal. 2016 22 : 871. |
| 23 | Dimitrakopoulos C, Theofilatos K, Pegkas A, Likothanassis S, Mavroudi S. Predicting overlapping protein complexes from weighted protein interaction graphs by gradually expanding dense neighborhoods. Artif Intell Med. 2016 71 : 62-69. [Full Text] [PubMed] [DOI] |
| 24 | Nikitaki Z, Mavragani IV, Laskaratou DA, Gika V, Moskvin VP, Theofilatos K, Vougas K, Stewart RD, Georgakilas AG. Systemic mechanisms and effects of ionizing radiation: A new 'old' paradigm of how the bystanders and distant can become the players. Semin Cancer Biol. 2016 37-38 : 77-95. [Full Text] [PubMed] [DOI] |
| 25 | Korfiati A, Theofilatos K, Kleftogiannis D, Alexakos C, Likothanassis S, Mavroudi S. Predicting human miRNA target genes using a novel computational intelligent framework. Information Sciences. 2015 294 : 576-85. |
| 26 | Theofilatos K, Pavlopoulou N, Papasavvas C, Likothanassis S, Dimitrakopoulos C, Georgopoulos E, Moschopoulos C, Mavroudi S. Predicting protein complexes from weighted protein-protein interaction graphs with a novel unsupervised methodology: evolutionary enhanced Markov clustering. Artificial intelligence in medicine. 2015 63 : 181-9. |
| 27 | Kleftogiannis D, Theofilatos K, Likothanassis S, Mavroudi S. YamiPred: A novel evolutionary method for predicting pre-miRNAs and selecting relevant features. IEEE/ACM transactions on computational biology and bioinformatics. 2015 12 : 1183-92. |
| 28 | Rapakoulia T, Theofilatos K, Kleftogiannis D, Likothanasis S, Tsakalidis A, Mavroudi S . EnsembleGASVR: a novel ensemble method for classifying missense single nucleotide polymorphisms. Bioinformatics. 2014 30 : 2324-33. |
| 29 | Theofilatos K, Dimitrakopoulos C, Likothanassis S, Kleftogiannis D, Moschopoulos C, Alexakos C, Papadimitriou S, Mavroudi S. The Human Interactome Knowledge Base (HINT-KB): an integrative human protein interaction database enriched with predicted protein–protein interaction scores using a novel hybrid technique. Artificial Intelligence Review. 2014 42 : 427-443. |
| 30 | Theofilatos K, Beligiannis G, Likothanassis S. Combining evolutionary and stochastic gradient techniques for system identification. Journal of Computational and Applied Mathematics. 2009 227 : 147-60. |